A SECRET WEAPON FOR BALING WIRE

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Around 80% of TTP is induced by deficient action of ADAMTS13. ADAMTS13 deficiency is often constitutive, on account of biallelic ADAMTS13 pathogenic variants; or obtained, due to an inhibitory antibody. Analysis of ADAMTS13 exercise is executed applying tests according to the capability of the protease to cleave conventional VWF multimers in vitro